What Is DLC In Blood Test?

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What Is DLC In Blood Test?

Blood tests are invaluable diagnostic tools that provide crucial insights into our health. One component of a comprehensive blood test is the Differential Leukocyte Count (DLC), a term that might sound complex but is essential for assessing a person’s overall well-being. In this blog, we will break down the meaning and significance of DLC in blood tests, exploring what it reveals about our immune system and health.

Differential Leukocyte Count (DLC) Explained

Differential Leukocyte Count, often abbreviated as DLC, is a specific part of a complete blood count (CBC). It measures the different types of white blood cells (leukocytes) present in a person’s bloodstream. White blood cells are a crucial part of the immune system, playing a central role in defending the body against infections and diseases.

The DLC provides a breakdown of the various types of white blood cells, which include:

  1. Neutrophils: Neutrophils are the most abundant type of white blood cells and are primarily responsible for fighting bacterial infections. An elevated neutrophil count might indicate a bacterial infection or inflammation.
  2. Lymphocytes: Lymphocytes are involved in the body’s immune response and help defend against viruses, bacteria, and other pathogens. An increase in lymphocyte count can be seen in viral infections.
  3. Monocytes: Monocytes are large white blood cells that play a role in cleaning up dead cells and debris from infections. They are also involved in the immune response. Elevated monocyte counts can indicate chronic infections or inflammatory conditions.
  4. Eosinophils: Eosinophils are essential for controlling allergic reactions and combating parasitic infections. An elevated eosinophil count may suggest allergies or parasitic infections.
  5. Basophils: Basophils release substances like histamine during allergic reactions and play a role in the inflammatory response. While less common, high basophil counts can occur in certain conditions.

Significance Of DLC In Blood Tests

DLC is a valuable tool for healthcare providers to assess a patient’s health and diagnose underlying conditions. By analyzing the distribution and levels of these white blood cell types, medical professionals can gain insights into the following:

  1. Infections: DLC can help identify whether an infection is bacterial, viral, or parasitic based on the predominant white blood cell count.
  2. Inflammatory Conditions: Elevated white blood cell counts, particularly neutrophils and monocytes, can indicate inflammation in the body, which may be associated with various conditions, including autoimmune diseases.
  3. Allergies: An increased eosinophil count may suggest an allergic reaction, making DLC useful in diagnosing allergies and related conditions.
  4. Immune System Disorders: Abnormal DLC results may also be indicative of immune system disorders, such as leukemia or lymphoma.
  5. Monitoring Treatment: DLC is essential for tracking a patient’s response to treatment, especially in cases of infections or blood disorders.

Interpreting DLC Results

Interpreting DLC results should always be done by a qualified healthcare provider who takes into account the patient’s medical history, symptoms, and other diagnostic tests. Abnormal DLC values can provide important clues but are usually not diagnostic on their own. DLC results are typically reported as percentages (relative counts) and absolute counts (the actual number of each type of white blood cell per microliter of blood).


In summary, Differential Leukocyte Count (DLC) is a crucial component of a complete blood count (CBC) that provides valuable information about the types and quantities of white blood cells in the bloodstream. This information is vital for diagnosing and monitoring a wide range of health conditions, from infections and allergies to autoimmune diseases and blood disorders. When interpreted by healthcare professionals in conjunction with other clinical data, DLC plays a significant role in assessing a person’s overall health and guiding appropriate medical treatment.


How Much DLC Is Normal?

Refer to the following to know the normal range of the DLC blood test: Neutrophils – 2500-8000 per mm3 (55-70%) Monocytes – 100-700 per mm3 (2–8%) Lymphocytes – 1000-4000 per mm3 (20–40%)

What Is DLC In Infection?

The differential leucocyte count (DLC) is a significant parameter in the blood picture of an animal, especially during any kind of stress from disease, trauma, and infection. The leucocytes of most strains of mice mainly contain neutrophils, lymphocytes, monocytes and eosinophils, while basophils are almost absent[3].

What Causes An Increase In DLC?

Increased counts of one or more WBC types may be an indication of infection or chronic condition that needs to be addressed. Increased or decreased DLC can also indicate possibility of health conditions of the immune system, autoimmune disorders, and cancers where the body attacks its own cells of the immune system.

What Is The Normal Range For Wbc DLC?

The normal number of WBCs in the blood is 4,500 to 11,000 WBCs per microliter (4.5 to 11.0 × 109/L). Normal value ranges may vary slightly among different labs. Some labs use different measurements or may test different specimens. Talk to your provider about your test results.

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